1987-1991 Scuola Normale Superiore, Pisa, Italy, Biology
1992-1994 Scuola Normale Superiore, Pisa, Italy,
1994 Max-Planck Institut für Psychiatrie, Martinsried,
Germany, (Prof. Y.-A. Barde), visiting student
The physiological roles of the neurotrophins NGF and
BDNF in the development of the visual system Supervisor: Prof. L. Maffei External
referee: Prof. H. Thoenen.
01.1995-06.1995: Max-Planck Institut für Psychiatrie,
Martinsried, Germany, (Prof. Y.-A. Barde)
08/1995-12/1997:University of Tübingen, Forschungstelle
für experimentelle Ophtalmologie, (Dr. K. Kohler) and Max-Planck Istitut für
Entwicklungsbiologe (Prof. M. Bähr).
01/1998-01/2000: CNR., Institute of Neurophysiology,
Pisa, (Dr. L. Galli-Resta and Dr. L. Colombaioni).
2000 : Tenure-track researcher, Scuola
1995:Human Capital Mobility grant from the EEC
1996: Research grant from the ForTueNe Programme,
University of Tuebingen
1996: Travel grant from the German Society for the
Scientific Research (DFG)
1997: Travel grant from the German Society for the
Scientific Research (DFG)
1999: Bilateral grant of the Vigoni programme CRUI
MURST research grant for junior scientists "Investigations
on the role played by brain-derived neurotrophic factor in the formation
of topographically-organised projections in the visual system".
MURST research grant for junior scientists "Effects
of brain-derived neurotrophic factor on the light-transduction in the
CNR-Agenzia 2000 "Effects of light-stimulation
and BDNF on intracellualr transduction pathways in the retina"
Official roles in international meetings:
1997: Montpellier (France), September 3-6, First
Mediterranean Neuroscience Conference: invited speaker
1997: New Orleans (LA, USA), October, 25-30, 23rd
Meeting of the Society for Neuroscience: chairman of a slide session
1998: Bochum (Germany), October 12-14, KOGNET Autumn
course: invited speaker
Scientific prizes awarded:
1998: Bruno Ceccarelli award for joung neuroscientists
My scientific interest is divided along three lines of
Neurotrophic factors and visual system development
The core of my activity was focussed on the role played by neutrophins in
plasticity and cell death. In particular, I am currently interested in the
activity-dependent mechanisms underlying the refinement of the
retino-tectal map and the control of cell death and development of
neuronal morphology in the retina.
Biological models of aging
Recently, I have characterised a fish species (Nothobranchius furzeri)
with a lifespan of only 12 weeks. This short lifespan notwithstanding,
these fishes undergo senescence and we are characterising brain aging in
A male of the extremely short-lived
Nothobranchius furzeri. These fishes have a maximum life expectancy in
captivity of only 12 weeks and undergo an extremely rapid senescence.
Their embryos can survive one year encased in the dry mud in a dormant
state and hatch during the rain season. See Valdesalici & Cellerino (2003)
Proc Roy Soc Lond B Biology Letters July 9
My experimental activity has been complemented by a strong intellectual
interest for Evolutionary Biology and Evolutionary Psychology. I have been
reviewing the neurobiological and evolutionary-informed psichological
literature concerning the control of human and animal mating. The results
of this synthesis are presented in my book Eros e cervello (Eros and the
Brain). We are currently studying perception of attractiveness and face
gender using EEG and morphing techniques.
Average male and female faces created using
GTKmorph by Andrea Mennucci, Scuola Normale Superiore, Pisa
e cervello. Le radici biologiche di sessualità, estetica, amore.
(Eros and the Brain. The Biological roots of Sexuality, Aesthetics, Love).
Traccedizioni. Piombino (LI). 2000.
List of full-length pubblications in peer-reviewed journals.
Cellerino A, Arango-Gonzalez B, Pinzon-Duarte G, Kohler K. (2003)
Brain-derived neurotrophic factor regulates expression of vasoactive
intestinal polypeptide in retinal amacrine cells. J Comp Neurol.
- A Mazzatenta, P Pelosi, A Cellerino (2003) Cloning of
an olfactory sensory-neuron specific protein in the land snail (Eobania
vermiculata). Proc Roy Soc Lond B Biology Letters in press
- S. Valdesalici, Cellerino A (2003) Extremely short
life-span in the annual fish Nothobranchius furzeri. Proc. Royal Soc. Lond.
B: Biology Letters, in press
-A. Cellerino (2003) Psychobiology of facial
attractiveness. J Endocrinol Invest. 2003;26:45-8
- S. Isenmann, Kretz A, Cellerino A. (2003) Molecular
determinants of retinal ganglion cell development, survival, and
regeneration. Prog Retin Eye Res. Jul;22(4):483-543
- A. Cellerino (2003) Una bellezza innata. Mente e
Cervello 2, 60-61
- A. Cellerino (2002) Facial attractiveness and species
recognition: an elementary deduction? Ecology, Ethology, Evolution 14:
- A. Cellerino (2002) Le basi innate della percezione estetica. Le
Scienze 404, 79-84
- Cellerino, A. Galli-Resta, L. and Colombaioni. L. (2000) The dynamics of
neuronal death: a time-lapse study in the retina. J. Neurosci 20:RC92
- Cellerino A, Novelli E & Galli-Resta L (2000)
Retinal ganglion cells with
NADPH-diaphorase activity in the chick form a regular mosaic with a strong
dorso-ventra asymmetry that can be modeled by a minimal spacing rule. Eur.
J. Neurosci 12:613-621.
- Cellerino A, Isenmann S & Baher M (2000) Apoptosis in the
system. Cell Tissue Res 301,53-69.
Isenmann S., A. Cellerino, C. Gravel and M. Baehr (1999).
Adenovirally-mediated overexpression of brain-derived neurotrophic factor in the target of
retinal ganglion cells stabilizes transient retinal projections. Mol. Cell.
- Cellerino A., B.-A. Arango-Gonzàlez and K. Kohler (1999). Effects of
brain-derived neurotrophic factor on the development of NADPH-diaphorase (nitric oxide
sinthase)-positive amacrine cells in the rodent retina. Eur. J. Neurosci. 11, 2824-2835
- Cellerino A., T. Michaelidis, J.J. Barski, M. Baehr, H. Thoenen and M.
Meyer (1999) Bcl-2 deficient mice undergo a rapid wave of retinal ganglion cell
degeneration following the period of naturally occurring cell death. Neuroreport,10, 1-5.
- Cellerino A., G. Pinzón-Duarte, P. Carroll and K. Kohler
(1998) Brain-derived neurotrophic factors modulates the development of the dopaminergic
network in the rodent retina. J. Neurosci.,18, 3351-3362
- Klöcker N, A. Cellerino and M. Bähr (1998) Free radical
scavenging and inhibition of nitric oxide synthase potentiates the effects of BDNF on
axotomized retinal ganglion cells in vivo. J. Neurosci., 18, 1038-1046
- Cellerino A., P. Carroll, H. Thoenen and Y.-A. Barde.
(1997) Reduced size of retinal ganglion cell axons and hypomyelination in mice lacking
brain-derived neurotrophic factor. Mol. and Cell. Neurosci. 9, 397-409
- Cellerino A. and Kohler K. (1997) The BDNF/NT-4 receptor is
localized on ganglion cells and dopaminergic amacrine cells in the vertebrate retina. J.
Comp. Neurol. 386, 149-160
- Cellerino A., Maffei L. and Domenici L. (1996) The
distribution of Brain-Derived Neurotrophic Factor and its receptor trkB in
parvalbumin-containing neurons of the rat visual cortex. Eur. J. Neurosci. 8,
- Cellerino A. and Maffei L. (1996) The action of
neurotrophins in the development and plasticity of the visual cortex. Progress in
Neurobiol. 49, 53-71
- Marty S., P. Carrol, A. Cellerino, E. Castrén, V. Staiger,
H. Thoenen and D. Lindholm (1996) Brain-derived neurotrophic factor promotes the
differentiation of various hippocampal non-pyramidal neurons, including Cajal-Retzius
cells, in organotypic slice cultures. J. Neurosci. 16, 675-687 (12)
- Cellerino A. (1996) Expression of messenger RNA coding for
the Nerve Growth Factor receptor trkA in the hippocampus of the adult rat. Neuroscience
- Cellerino A., C. Strohmaier and Y.-A. Barde (1995)
Brain-Derived Neurotrophic Factor and the developing chick retina. In Life and
death in the nervous system ed. C.F. Ibánez.. p. 131-139 Oxford, England: Elsevier
- Domenici L., A. Cellerino, N. Berardi and L. Maffei (1994)
Antibodies to nerve growth factor (NGF) prolong the sensitive period for monocular
deprivation in the rat. Neuroreport 5, 2041-2044
- Berardi N., A. Cellerino, L. Domenici, M. Fagiolini, T.
Pizzorusso, A. Cattaneo and L. Maffei (1994) Monoclonal antibodies to Nerve Growth Factor
affect the postnatal development of the visual system. Proc. Natnl. Acad. Sci. U.S.A.
- Domenici L., A. Cellerino and L. Maffei (1993) Monocular
deprivation effects in the rat visual cortex and lateral geniculate nucleus are prevented
by nerve growth factor (NGF). II. Lateral geniculate nucleus. Proc. R. Soc. Lond. B
- Berardi N., L. Domenici, V. Parisi, T. Pizzorusso, A.
Cellerino and L. Maffei (1993) Monocular deprivation effects in the rat visual cortex and
lateral geniculate nucleus are prevented by nerve growth factor (NGF) I. Visual cortex. Proc.
R. Soc. Lond. B 251, 17-23
- Cellerino A., R. Siciliano, L. Domenici and L. Maffei
(1992) Parvalbumin immunoreactivity: a reliable marker for the effects of monocular
deprivation in the rat visual cortex. Neuroscience 51, 749-753